Figure 8From: Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue modelBasal CYP3A4 activity of 3D human liver microtissue over 28 days in culture. The liver microtissues were exposed in GravityTRAP™ plates to midazolam for 24 hr. The supernatant from the microtissues were analysed for CYP3A4 mediated midazolam-1-hydroxylation. The values are representative of mean ± SD (n = 3).Back to article page