Single exposure | End-points investigated |
---|---|
Treatment 1 – 0 hr (day 0) | - |
Change medium – 24 hr (day 1) | AK assay, cytokine secretion, albumin |
Change medium – 72 hr (day 3) | Albumin |
Change medium – 168 hr (day 7) | AK assay, cytokine secretion |
Change medium – 216 hr (day 9) | Albumin |
Change medium – 264 hr (day 11) | - |
Change medium – 336 hr (day 14) | - |
Change medium – 360 hr (day 15) | AK assay, cytokine secretion, lipid peroxidation, DNA damage, albumin |
Multiple exposure | End-points investigated |
Treatment 1 – 0 hr (day 0) | - |
Change medium – 24 hr (day 1) – 48 hr recovery period | AK assay, cytokine secretion |
Treatment 2 – 72 hr (day 3) | AK assay, cytokine secretion, albumin |
Change medium – 96 hr (day 4) - 48 hr recovery period | AK assay, cytokine secretion, albumin |
Treatment 3 – 144 hr (day 6) | AK assay, cytokine secretion |
Change medium – 168 hr (day 7) - 48 hr recovery period | AK assay, cytokine secretion, albumin |
Treatment 4 – 216 hr (day 9) | AK assay, cytokine secretion, albumin |
Change medium – 240 hr (day 10) - 48 hr recovery period | AK assay, cytokine secretion, albumin |
Treatment 5 – 288 hr (day 12) | - |
Change medium – 312 hr (day 13) | AK assay, cytokine secretion |
Change medium – 360 hr (day 15) | Lipid peroxidation, DNA damage, albumin |