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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

Figure 4

Silica-induced caspase-1 activity in human bronchial epithelial and macrophage-like cells is attenuated by thioredoxin. Caspase-1 enzymatic activity was assayed in cell lysates of BEAS-2B (A) and THP-1 cells (B) exposed to different silica polymorphs for 24 h at a dose of 150 x 106 μm2/cm2, transiently overexpressing flag-tagged thioredoxin (flagTRX) or pcDNA empty plasmid. Caspase-1 activities are expressed as mean arbitrary units (O.D. 405 nm /total protein concentration (mg/mL)) ± SEM with * p-value <0.05 compared to appropriate controls (UC), and # p-value <0.05 compared to same treatment in pcDNA conditions.

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