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Figure 8 | Particle and Fibre Toxicology

Figure 8

From: Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

Figure 8

Particle surface modification modulates inflammasome activation in rat lungs. Immuno-histochemical staining of caspase-1 (A) and IL-1β (B) in PBS control vs. DQ12 or DQ12-PVNO treated rats at 180 days after exposure along with corresponding IgG control staining. Images are representative of 5 rats per group. Caspase-1 and IL-1β are stained in blue. Slides were counterstained using Nuclear Fast Red. Arrows indicate specific cell types, i.e. bronchial epithelium (solid triangle), alveolar epithelial cell (arrow), macrophages (open triangle).

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