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Figure 8 | Particle and Fibre Toxicology

Figure 8

From: Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue

Figure 8

TiO 2 NPs-induced toxicological effects. A. DNA damage detected in single isolated cardiomyocytes by Comet assay (pH >13) in CTRL (white columns) and NPC (red columns) after 1 h and 5 h of exposure. DNA damage is expressed as tail intensity (TI%; *p < 0.05). B. Percent increase of ROS in single isolated cardiomyocytes, NPC (red column) after 1 h. C. Evaluation of TBARS in trachea, lungs and heart tissue after tracheal instillation of saline solution (Vehicle) or saline solution containing TiO2-NPs (2 mg/Kg, NPR). *, p < 0.05 vs. Vehicle.

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