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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum

Figure 4

Summary of the initial steps of complement activation on SPIO NW surface: mouse vs. man. There is an involvement of the LP in both mouse and human sera. The main difference is the direct involvement of the AP turnover in human sera, and activation of the CP in some human individuals. The role of multiple LP components in humans is not clear at this point.

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