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Figure 1 | Particle and Fibre Toxicology

Figure 1

From: The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles

Figure 1

Silica induces IL-1α and IL-33 release in the lung before IL-1β production and neutrophilic inflammation. Levels of (a) IL-1α and (b) IL-33 in BAL fluid collected at different time points after silica (crystalline DQ12, 2.5 mg) or not (control). Pulmonary expression of (c) pro-IL-1β quantified by qRT-PCR at different time points after instillation of silica or not. Number of alveolar (d) total cells and (e) neutrophils (GR1+ cells) assessed by flow cytometry. (f) Expression of the pulmonary neutrophilic CXCR2 marker quantified by qRT-PCR at different time points after silica or not. Values are means ± SEM of 3 to 8 animals. *p < 0.05, **p < 0.01 and ***p < 0.001 denote significant difference between animals treated with silica or not; ns, denotes no significant difference. P-values are estimated by t-test.

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