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Figure 3 | Particle and Fibre Toxicology

Figure 3

From: The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles

Figure 3

IL-1α inhibition reduces IL-1β production in lung of silica-treated mice. (a) Pulmonary expression of pro-IL-1β quantified by qRT-PCR and (b) levels of mature IL-1β in BAL fluid of WT and IL-1α KO mice, 24 hours after instillation of silica (crystalline DQ12, 2.5 mg) or not (control). (c) Pulmonary expression of pro-IL-1β quantified by qRT-PCR and (d) levels of mature IL-1β in BAL fluid 18 hours after silica or not, in mice treated with IL-1α neutralizing antibody or not. Values are means ± SEM of 3 to 8 animals. **p < 0.01 denote significant difference between animals treated or not with silica. # p < 0.05, ## p < 0.01 denote significant difference between silica-treated animals with decreased or unmodified IL-1α. P-values are estimated by t-test.

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