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Figure 2 | Particle and Fibre Toxicology

Figure 2

From: Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics

Figure 2

Diesel exhaust-associated exposure patterns were captured in principal component 22. A) PC22 was associated with model-3 (DE6&30 hr vs. non-DE6&30 hr). Samples were sorted according to DE6&30 hr samples versus non-DE6&30 hr baseline samples and their PC22 associated principal component scores were displayed. There was a visible pattern indicative of DE-exposure with the DE6&30 hr samples showing mostly positive scores, and the baseline samples showing mostly negative scores. B) For each probe in the dataset, its loading value in association with PC22 was calculated. The +/-3SD and +/-6SD positions are marked by vertical dashed lines. And the probes harboring the largest contribution to diesel exposure methylation pattern were selected for using the +/-3SD cut off, resulting in 2827 hits.

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Particle and Fibre Toxicology

ISSN: 1743-8977

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