Figure 4From: Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmaticsDNA methylation of CpG sites overlapping with Alu and LINE1 repetitive elements was associated with diesel exhaust. A) Distributions of unadjusted p-values from LME modeling applied to CpG sites overlapping with Alu and LINE1 elements. The uniform distribution expected by chance is indicated with horizontal dashed lines. Positive skewing of DE p-value distributions indicated association with differential methylation, whereas lack of skewing of FA p-value distributions indicated absence of association. B) Distributions of ∆β obtained from subtracting pre-FA beta values from post-FA beta values, and from subtracting pre-DE beta values from post- DE beta values for LINE1 and Alu probes that were significantly altered in response to DE exposure. ∆β from DE samples were much larger in magnitude than that from FA samples.Back to article page