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Figure 1 | Particle and Fibre Toxicology

Figure 1

From: Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?

Figure 1

Modeling of a 4-week repeated inhalation study in rats with minimally and/or poorly soluble particle at minimal overload conditions. The simulations illustrate that ‘dissolution’ can readily be detected and quantified during post-exposure periods of 90-days but may remain undetected during the actual exposure period. Elimination half-times (t1/2) of 80 and 120 days suggest normal to beginning overload-related clearance, respectively. Half-times shorter than 60-days demonstrate a dissolution rate that might not necessarily be compatible with the PSP paradigm.

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