Table 1 Gansu particle aspirations in male FVB/N mice (0.25 μg)
From: Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice
Gansu PM repeated aspiration | H 2 0 (n) | JC (n) | ZH (n) | ZH + NiSO 4 (n) |
|---|---|---|---|---|
PE Max contraction (% ± SE) | 100 ± 2.59 | 100.2 ± 5.84 | 98.7 ± 2.71 | 99.8 ± 7.17 |
Log EC 50 (M ± SE) | −6.04 ± 0.17 (8) | −6.13 ± 0.08 (14) | −6.00 ± 0.04 (6) | −6.32 ± 0.12 (16) |
SNP Max relaxation (% ± SE) | 1.96 ± 12.4 | 14.11 ± 7.73 | 5.24 ± 6.18 | 18.8 ± 8.59 |
Log ED 50 (M ± SE) | −7.05 ± 0.15 | −7.03 ± 0.25 | −6.69 ± 0.14 | −7.23 ± 0.28 |
ACh Max relaxation (% ± SE) | 1.74 ± 3.08 | 33.0 ± 3.16*** | 8.84 ± 6.29 | 23.6 ± 3.27*** |
Log ED 50 (M ± SE) | −7.00 ± 0.07 | −6.65 ± 0.10 | −6.82 ± 0.15 | −6.47 ± 0.08 |
Above data expressed as Mean ± SEM. Significant differences determined by comparison to H20 controls; ***p < 0.001. | ||||
Apocynin | Â | Â | Â | Â |
ACh Max relaxation (% ± SE) | NA | 7.72 ± 4.30** | NA | 15.0 ± 6.63 |
Log ED 50 (M ± SE) |  | −6.83 ± 0.11 (5) |  | −6.47 ± 0.13 (5) |
LNAME | Â | Â | Â | Â |
ACh Max relaxation (% ± SE) | NA | 16.3 ± 7.51* | NA | 12.2 ± 7.97 |
Log ED 50 (M ± SE) |  | −6.72 ± 0.18(5) |  | −6.63 ± 0.16 (5) |
VAS2870 | Â | Â | Â | Â |
ACh Max relaxation (% ± SE) | NA | 0.44 ± 4.26*** | NA | 0.11 ± 5.53*** |
Log ED 50 (M ± SE) |  | −6.93 ± 0.11 (5) |  | −6.70 ± 0.11 (5) |