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Table 1 Gansu particle aspirations in male FVB/N mice (0.25 μg)

From: Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice

Gansu PM repeated aspiration H 2 0 (n) JC (n) ZH (n) ZH + NiSO 4 (n)
PE Max contraction (% ± SE) 100 ± 2.59 100.2 ± 5.84 98.7 ± 2.71 99.8 ± 7.17
Log EC 50 (M ± SE) −6.04 ± 0.17 (8) −6.13 ± 0.08 (14) −6.00 ± 0.04 (6) −6.32 ± 0.12 (16)
SNP Max relaxation (% ± SE) 1.96 ± 12.4 14.11 ± 7.73 5.24 ± 6.18 18.8 ± 8.59
Log ED 50 (M ± SE) −7.05 ± 0.15 −7.03 ± 0.25 −6.69 ± 0.14 −7.23 ± 0.28
ACh Max relaxation (% ± SE) 1.74 ± 3.08 33.0 ± 3.16*** 8.84 ± 6.29 23.6 ± 3.27***
Log ED 50 (M ± SE) −7.00 ± 0.07 −6.65 ± 0.10 −6.82 ± 0.15 −6.47 ± 0.08
Above data expressed as Mean ± SEM. Significant differences determined by comparison to H20 controls; ***p < 0.001.
Apocynin     
ACh Max relaxation (% ± SE) NA 7.72 ± 4.30** NA 15.0 ± 6.63
Log ED 50 (M ± SE)   −6.83 ± 0.11 (5)   −6.47 ± 0.13 (5)
LNAME     
ACh Max relaxation (% ± SE) NA 16.3 ± 7.51* NA 12.2 ± 7.97
Log ED 50 (M ± SE)   −6.72 ± 0.18(5)   −6.63 ± 0.16 (5)
VAS2870     
ACh Max relaxation (% ± SE) NA 0.44 ± 4.26*** NA 0.11 ± 5.53***
Log ED 50 (M ± SE)   −6.93 ± 0.11 (5)   −6.70 ± 0.11 (5)
  1. Reported values are mean ± SEM. *indicates significant difference between respected treatment groups before and after incubation of inhibitors (*p < 0.05; **p < 0.01; ***p < 0.001).