MPPD Version | MPPD input parameters* | Alveolar deposition fraction in rats /% | Alveolar deposition fraction in humans/% | Critical steady state particle volume burden/μL per kg-rat | Alveolar clearance half time in humans/days | NOAEC/mg/m 3 | AF lung burden /1 | AF clear ance /1 | HEC/mg/m 3 |
---|---|---|---|---|---|---|---|---|---|
2.0 | IA switched off OMB | 7.5 | 16.4 | 1 | 400 | 0.53 | 0.93 | 0.93 | 0.53 |
2.0 | IA ONA | 6.3 | 8.4 | 1 | 400 | 0.63 | 1.52 | 0.93 | 1.03 |
2.11 | 3.3 | 8.8 | 1 | 400 | 1.21 | 0.76 | 0.93 | 0.98 | |
2.0 | IA ONA | 6.3 | 8.4 | 4.2 | 400 | 2.66 | 1.52 | 0.93 | 4.33 |
2.11 | 3.3 | 8.8 | 4.2 | 400 | 5.07 | 0.76 | 0.93 | 4.14 | |
2.0 | IA ONA | 6.3 | 8.4 | 1 | 250 | 0.63 | 1.52 | 0.58 | 1.65 |
2.11 | 3.3 | 8.8 | 1 | 250 | 1.21 | 0.76 | 0.58 | 1.58 | |
2.0 | IA ONA | 6.3 | 8.4 | 4.2 | 250 | 2.66 | 1.52 | 0.58 | 6.93 |
2.11 | 3.3 | 8.8 | 4.2 | 250 | 5.07 | 0.76 | 0.58 | 6.62 |