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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Response-metrics for acute lung inflammation pattern by cobalt-based nanoparticles

Fig. 2

Comparison of inflammatory parameters for cobalt monoxide (CoO) nanoparticles (NPs) and cobalt chloride (CoCl2). Number of (A) total cells, (B) macrophages, (C) neutrophils, (D) eosinophils, and levels of (E) LDH, (F) total protein, (G) IL-6, and (H) eotaxin. Both treatment groups had same doses for cobalt ions (31, 79, and 315 μg/rat). Note that the inflammatory parameters of CoO NPs were similar with the CoCl2 which implies that the toxicity of CoO NPs was derived from their solubilized cobalt ions. Values are mean ± SEM (n = 4) for each treatment group. The data from CoO NPs were compared with the vehicle control (Ca2+- and Mg2+-free phosphate buffered saline) to determine statistical significance. * p < 0.05, ** p < 0.01, *** p < 0.001. The data from CoCl2 were compared with the vehicle control (0.9 % saline). $ p < 0.05, $$ p < 0.01, $$$ p < 0.001

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