Fig. 3
From: Response-metrics for acute lung inflammation pattern by cobalt-based nanoparticles
Correlation between the inflammatory parameters of nanoparticles (NPs) and dose-metrics including soluble Co ions, mass, surface area (SA), and SA dose of biopersistent NPs. Correlation between the number of eosinophils and (A) Co ions, (B) mass dose of NPs, (C) SA dose of NPs, or (D) SA dose of biopersistent NPs. Correlation between the number of neutrophils and (E) Co ions, (F) mass dose of NPs, (G) SA dose of NPs, or (H) SA dose of biopersistent NPs. When the dose–response curves of cobalt oxide (Co3O4) and cobalt monoxide (CoO) NPs were significantly different, separate curves were drawn with either linear regression or non-linear regression, while when the dose–response curves of each NP overlapped, the combined curves were prepared with best-fit regression models and the Pearson correlation test was applied. Values are mean ± SEM (n = 4) for each treatment group