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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Response-metrics for acute lung inflammation pattern by cobalt-based nanoparticles

Fig. 4

Correlation between the toxic parameters [the levels of lactate dehydrogenase (LDH) and total protein] of nanoparticles (NPs) and dose-metrics, including soluble cobalt (Co) ions, mass, surface area (SA), and SA dose of biopersistent NPs. Correlation between the levels of LDH and (A) Co ions, (B) mass dose of NPs, (C) SA dose of NPs, or (D) SA dose of biopersistent NPs. Correlation between the levels of total protein and (E) Co ions, (F) mass dose of NPs, (G) SA dose of NPs, or (H) SA dose of biopersistent NPs. When the dose–response curves of cobalt oxide (Co3O4) and cobalt monoxide (CoO) NPs were significantly different, separate curves were drawn with either linear regression or non-linear regression, while when the dose–response curves of each NP overlapped, the combined curves were prepared with best-fit regression models, and the Pearson correlation test was applied. Values are mean ± SEM (n = 4) for each treatment group

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