Table 3 Summary of inflammatory cell counts, LDH, total protein, and inflammatory mediators at 24 h after intratracheal instillation of CoCl2
From: Response-metrics for acute lung inflammation pattern by cobalt-based nanoparticles
BALF measure | VEHsaline | CoCl2 (μg/rat)a | ||
|---|---|---|---|---|
69 (31)b | 173 (79) | 693 (315) | ||
Total cells (× 105) | 13.65 ± 2.63 | 24.68 ± 5.12 | 28.35 ± 3.96 | 18.30 ± 1.54 |
Macrophages (× 105) | 11.84 ± 1.36 | 14.12 ± 1.81 | 13.66 ± 0.80 | 2.92 ± 0.746** |
Neutrophils (× 105) | 1.76 ± 1.38 | 10.48 ± 3.72* | 13.74 ± 3.77** | 11.70 ± 2.75*** |
Eosinophils (× 105) | 0.02 ± 0.02 | 0.06 ± 0.04 | 0.95 ± 0.56 | 3.63 ± 0.81** |
Lymphocytes (× 105) | 0.05 ± 0.01 | 0.10 ± 0.04 | 0.04 ± 0.02 | 0.02 ± 0.02 |
LDH (fold vs control) | 1.00 ± 0.12 | 3.08 ± 0.53* | 6.65 ± 0.78*** | 15.05 ± 0.18*** |
Total protein (μg/mL) | 270 ± 47 | 341 ± 67 | 700 ± 165 | 5051 ± 917*** |
CINC-3 (pg/mL) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
IL-6 (pg/mL) | 0.00 ± 0.00 | 0.00 ± 0.00 | 39.2 ± 39.2 | 734.6 ± 152.3*** |
Eotaxin (pg/mL) | 10.76 ± 3.27 | 30.94 ± 16.60 | 133.1 ± 49.2 | 699.8 ± 38.1*** |
IL-13 (pg/mL) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |