Fig. 7
Translocation of (a) ionic gold and (b) AuNP for two cell models of different complexity. (a) Comparison of the translocation fraction of ionic gold after 24 h: CMLs treated with 100 ng/cm2 gold were compared to in vivo data from Kreyling et al. [20], who determined the biodistribution in female Wistar-Kyoto rats after intratracheal instillation (1 μg gold). Two extreme scenarios are presented for the translocation fraction from Kreyling et al. For the lower bound, we assumed that all of the gold that was recovered from the GIT and feces had not been translocated, but instead had been cleared via the mucociliary pathway directly from the lungs to the GIT. For the upper bound, we assumed that all of the gold in the GIT and the feces was first taken up and then cleared via the biliary pathway to the GIT. (b) Comparison of the translocation fraction of 18 nm large particles in an A549 CML and a TCCC system 24 h after exposure to 100 ng/cm2 AuNP. (data are expressed as mean ± SD, n = 3 (CML/TCCC) and n = 4 (rats))