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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Preventing carbon nanoparticle-induced lung inflammation reduces antigen-specific sensitization and subsequent allergic reactions in a mouse model

Fig. 4

Ectoine application reduces the frequency of antigen loaded dendritic cells in lymph nodes. a Animals (n = 3 in control groups, n = 8 in exposure groups) were exposed to 50 μg Alexa Fluor 488-labelled OVA 12 h after the application of PBS (control), CNP, or CNP + E. In order to control for effects of labelled OVA, an additional PBS group without OVA was employed. b BAL cell numbers (means, SEM) 36 h after initial treatment. c Total lymph node cells. d Percentage of OVA-488 positive dendritic cells (MHCII+, CD11c+). e. Percentage of OVA-488 positive macrophages (MHCII+, F4/80+). *significant differences were observed in total cell numbers, neutrophil numbers, and percentage of OVA-488 positive dendritic cells (p < 0.05, Mann Whitney U-test)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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