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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Acute and subchronic exposure to air particulate matter induces expression of angiotensin and bradykinin-related genes in the lungs and heart: Angiotensin-II type-I receptor as a molecular target of particulate matter exposure

Fig. 7

Subchronic exposure to fine and ultrafine PM induces heart reprogramming and up-regulates AT1R and IL-6. The animals were subchronically exposed (5 h/day, 4 days/week for 8 weeks) to coarse (CP), fine (FP) and ultrafine particulate (UFP) or to filtered air (FA). a) Semi-quantitative levels of alpha-skeletal actin (Acta1a) mRNA and b) Semi-quantitative levels of collagen-III (Col3a1) mRNA in the heart. Protein levels of AT1R and interleukin-6 (IL-6) are expressed in arbitrary units (AU), c) and d), respectively. Scatter dot plot shows the value of the median. * indicates significant differences among groups (n = 4 per group, p < 0.05)

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