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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

Fig. 2

Induction of AD-like skin lesions by Dp + nSP30 agglomerates in PBS. a Effect of topical administration of Dp alone or Dp + nSP30 in PBS on ear thickness in NC/Nga mice. b and c, Histology of ear sections stained with (b) hematoxylin and eosin (HE) or (c) toluidine blue (TB). Scale bar, 50 μm. (d) Scores for several symptoms characteristic of AD evaluated in HE-stained sections. e Mast cell infiltration evaluated in TB-stained sections as the number of mast cells per high-power (400×) field (HPF). f Total plasma IgE concentrations measured 24 h after the final skin painting. Data are presented as means ± SEMs (n = 5). *P < 0.05 vs. Dp-alone group

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Particle and Fibre Toxicology

ISSN: 1743-8977

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