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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

Fig. 5

Effects of Dp + nSP30 aggregates compared with Dp and nSP30 administered on alternate days. a Effect of topical application of Dp + nSP30 and PBS (Dp + nSP30/PBS) compared with Dp and nSP30 (Dp/nSP30) on alternate days on ear thickness in NC/Nga mice. b–e Plasma levels of (b) total IgE, (c) Dp-specific IgE, (d) IgG and (e) IgG1 and IgG2a 24 h after final treatment, as analyzed by ELISA. f Numbers of Dp-specific IFN-γ- and IL-4-producing splenocytes after re-stimulation with 100 μg mL−1 Dp, as determined by ELISPOT assays specific for each cytokine. Data are presented as means ± SEMs (n = 5). *P < 0.05, **P < 0.01 vs. Dp/PBS group

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Particle and Fibre Toxicology

ISSN: 1743-8977

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