|
Males
|
Females
|
---|
Target concentration (mg/m3)
|
0
|
0.05
|
0.25
|
5.0
|
0
|
0.05
|
0.25
|
5.0
|
Number examined
|
10/10
|
10/0
|
10/10
|
10/10
|
10/10
|
10/0
|
10/10
|
10/10
|
(24 h/90 days)
|
Nasal cavity epithelium, eosinophilic globules
| | | | | | | | |
minimal
|
4/2
|
-
|
2/3
|
2/6
|
-/3
|
-
|
3/2
|
1/4
|
slight
|
-/1
|
-
|
-
|
3/2
|
-
|
-
|
-
|
6/2
|
moderate
|
-
|
-
|
-
|
5/2
|
-
|
-
|
-
|
2/3
|
Mean severitya
|
0.4/0.4
|
-
|
0.2/0.3
|
2.3/1.6
|
-/0.3
|
-
|
0.3/0.2
|
1.9/1.7
|
Larynx, squamous metaplasia
| | | | | | | | |
minimal
|
-
|
-
|
2/-
|
4/-
|
-
|
-
|
-
|
5/1
|
Mean severitya
|
-
|
-
|
0.2/-
|
0.4/-
|
-
|
-
|
-
|
0.5/0.1
|
- Histopathological findings were graded in severity using a five point system of minimal (grade 1), slight (grade 2), moderate (grade 3), marked (grade 4) or severe (grade 5)a: mean severity is ∑ number of animals x severity / number of examined organs in the group
-
a: mean severity is ∑ number of animals x severity / number of examined organs in the group - : no animal affected