Table 10 Microscopic findings in the nasal cavity and larynx of male and female rats 24 h and 90 days after a 90-day exposure to Graphistrength^© C100

Target concentration (mg/m³)

0

0.05

0.25

5.0

0

0.05

0.25

5.0

Number examined

10/10

10/0

10/10

10/10

10/10

10/0

10/10

10/10

(24 h/90 days)

Nasal cavity epithelium, eosinophilic globules

minimal

4/2

-

2/3

2/6

-/3

-

3/2

1/4

slight

-/1

-

-

3/2

-

-

-

6/2

moderate

-

-

-

5/2

-

-

-

2/3

Mean severity^a

0.4/0.4

-

0.2/0.3

2.3/1.6

-/0.3

-

0.3/0.2

1.9/1.7

Larynx, squamous metaplasia

minimal

-

-

2/-

4/-

-

-

-

5/1

Mean severity^a

-

-

0.2/-

0.4/-

-

-

-

0.5/0.1