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Table 11 Results of the micronucleus assay in the bone marrow of male and female rats 24 h after a 90-day exposure to Graphistrength© C100

From: Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats

Test groups

Concentration / dose level

PCEs with micronuclei (%)

Rangea

PCE per 2000 erythrocytes

(n = 5/group)

(mg/m3)

   

MALE

Air control

0

0.340

2 - 17

1099

Graphistrength© C100

0.05

0.440

5 - 11

1073

0.25

0.280

2 - 10

1094

5.00

0.210

3 - 8

1081

Positive controlb

20

0.833*

10 - 26

806

FEMALE

Vehicle

0

0.290

3 - 9

1155

Graphistrength© C100

0.05

0.210

1 - 8

1223

0.25

0.190

1 - 5

1147

5.00

0.220

2 - 9

1091

Positive controlb

20

0.750**

8 - 28

813

  1. */**: Non-parametric Mann-Whitney test significant <0.05 (*) or <0.01 (**)
  2. aper 2000 PCEs per animal
  3. bCPA, 20 mg/kg bw