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Table 11 Results of the micronucleus assay in the bone marrow of male and female rats 24 h after a 90-day exposure to Graphistrength© C100

From: Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats

Test groups Concentration / dose level PCEs with micronuclei (%) Rangea PCE per 2000 erythrocytes
(n = 5/group) (mg/m3)    
MALE
Air control 0 0.340 2 - 17 1099
Graphistrength© C100 0.05 0.440 5 - 11 1073
0.25 0.280 2 - 10 1094
5.00 0.210 3 - 8 1081
Positive controlb 20 0.833* 10 - 26 806
FEMALE
Vehicle 0 0.290 3 - 9 1155
Graphistrength© C100 0.05 0.210 1 - 8 1223
0.25 0.190 1 - 5 1147
5.00 0.220 2 - 9 1091
Positive controlb 20 0.750** 8 - 28 813
  1. */**: Non-parametric Mann-Whitney test significant <0.05 (*) or <0.01 (**)
  2. aper 2000 PCEs per animal
  3. bCPA, 20 mg/kg bw
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Particle and Fibre Toxicology

ISSN: 1743-8977

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