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Table 2 Statistically significant changesa in hematological parameters 24 h and 90 days after a 90-day exposure of male and female rats to Graphistrength© C100

From: Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats

Concentration Total leucocytes Neutrophils Eosinophils Lymphocytes Prothrombin time Platelets
(mg/m3) G/L rel. 1 (G/l) rel. 1 (G/l) rel. 1 (G/l) rel. 1 (sec) G/l
MALE
HCD b, c 3.74 - 9.53 0.119 - 0.339 0.01 - 0.035 0.611 - 0.842 0.70 – 0.97 708 - 1168
(0.66 - 2.29) (0.05 - 0.22) (2.59 - 7.39) (14.4 - 29.9)  
24 h post exposure
0 6.43 0.197 (1.28) 0.009 (0.06) 0.742 (4.78) 0.73 (23.4) 879
0.05 7.01 0.220 (1.79) 0.013 (0.10) 0.716 (4.79) 0.73 (23.4) 973
0.25 7.30 0.211 (1.71) 0.013* (0.10) 0.727 (5.15) 0.76 (22.8) 972
5.0 8.13 0.327** (2.63**) 0.015* (0.12) 0.608** (5.05) 0.77* (22.5) 1003*
90 days post exposure
0 7.07 0.237 (1.79) 0.012 (0.09) 0.707 (4.88) 0.85 (23.7) 903
0.05 7.47 0.223 (1.62) 0.014 (0.11) 0.716 (5.44) 0.86 (23.4) 914
0.25 7.14 0.283 (2.23) 0.015 (0.11) 0.664 (4.55) 0.85 (23.7) 822
5.0 8.23 0.374* (2.96**) 0.015 (0.12) 0.577* (4.84) 0.89 (22.8) 901
FEMALE
HCDb, c 1.91 - 6.14 0.099 - 0.343 0.009 - 0.045 0.598 - 0.860 0.70 – 0.98 723 - 1235
(0.34-1.31) (0.03 - 0.15) (1.30 - 4.86) (13.5 - 38.2)  
24 h post exposure
0 4.07 0.146 (0.61) 0.011 (0.04) 0.809 (3.29) 0.73 (23.5) 1144
0.05 4.05 0.152 (0.61) 0.006 (0.04) 0.808 (3.27) 0.75 (23.0) 1087
0.25 3.69 0.170 (0.62) 0.016 (0.06) 0.779 (2.87) 0.79** (22.2**) 1042
5.0 4.96 0.261** (1.21**) 0.012 (0.06) 0.698** (3.54) 0.77 (22.6) 1099
90 days post exposure
0 4.17 0.175 (0.67) 0.017 (0.06) 0.772 (3.27) 0.87 (23.2) 883
0.05 3.75 0.220 (0.84) 0.019 (0.07) 0.729 (2.71) 0.88 (22.8) 933
0.25 3.32 0.238* (0.74) 0.018 (0.05) 0.714 (2.40) 0.86 (23.5) 841
5.0 4.90 0.382** (1.81**) 0.013 (0.07) 0.564** (2.85) 0.89 (22.7) 914
  1. * p < 0.05, ** p < 0.01; statistical significant differences to controls
  2. a No statistically significant changes were observed at any concentrations and time-points on red blood cell, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, reticulocytes, basophils, monocytes and partial thromboplastine time
  3. b HCD Historical control data, 95 % tolerance limits
  4. c Changes statistically significant outside the HCD are in italic characters