Skip to main content

Table 3 Statistically significant changesa in blood chemistry parameters 24 h and 90 days after a 90-day exposure of male and female rats to Graphistrength© C100

From: Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats

Concentration (mg/m3)

Creatinine μmol/l

Triglycerides mmol/l

Sodium mmol/l

Potassium mmol/l

Chloride mmol/l

Calcium mmol/l

Total protein g/l

MALE

HCDb, c

21.9 - 35.0

0.20 - 1.08

138. 5- 149.2

3.22 - 4.47

99.9 - 109.2

2.55 - 2.97

62.10 - 73.54

24 h post exposure

0

23.7

0.48

142.8

4.13

102.3

2.68

66.15

0.05

24.6

0.38*

142.9

4.20

102.1

2.67

65.39

0.25

23.6

0.37*

143.9

4.25

103.0

2.69

67.02

5.0

22.4

0.41

144.2

4.52**

103.0

2.69

66.97

90 days post exposure

0

27.9

0.77

145.5

4.52

103.4

2.75

69.08

0.05

25.5*

0.68

145.7

4.59

103.2

2.77

68.42

0.25

24.4**

0.75

145.9

4.58

104.4

2.71

67.41

5.0

26.3

0.79

145.8**

4.73

104.5

2.74-

68.24

FEMALE

HCDb, c

25.0 - 41.7

0.18 - 0.57

137.8 - 147.8

2.73 - 3.90

100.6 - 110.3

2.53 - 2.99

63.62 - 79.36

24 h post exposure

0

30.4

0.32

143.5

3.43

102.0

2.75

72.27

0.05

27.7

0.31

144.8

3.95**

103.8

2.76

71.50

0.25

28.3

0.35

144.0

4.17**

103.4

2.80

72.87

5.0

27.3*

0.30

145.8

3.81*

105.3**

2.72

69.27*

90 days post exposure

0

28.8

0.72

143.5

3.40

101.7

2.78

77.11

0.05

31.9

0.60

146.4**

3.41

104.1

2.76

74.74

0.25

30.1

0.54*

144.9

3.21

101.9

2.72*

74.78

5.0

30.6

0.47**

145.1

3.54

104.0

2.74

72.29**

  1. * p < 0.05, ** p < 0.01; statistical significant differences to controls
  2. a No statistically significant changes were observed at any concentrations and time-points on glucose, urea, bilirubin, cholesterol, triglycerides, phospholipids, aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), creatine kinase (CK), phosphorus, albumin and globulin
  3. b HCD Historical control data, 95 % tolerance limits
  4. c Changes statistically significant outside the HCD are in italic characters