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Table 3 Statistically significant changesa in blood chemistry parameters 24 h and 90 days after a 90-day exposure of male and female rats to Graphistrength© C100

From: Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats

Concentration (mg/m3) Creatinine μmol/l Triglycerides mmol/l Sodium mmol/l Potassium mmol/l Chloride mmol/l Calcium mmol/l Total protein g/l
MALE
HCDb, c 21.9 - 35.0 0.20 - 1.08 138. 5- 149.2 3.22 - 4.47 99.9 - 109.2 2.55 - 2.97 62.10 - 73.54
24 h post exposure
0 23.7 0.48 142.8 4.13 102.3 2.68 66.15
0.05 24.6 0.38* 142.9 4.20 102.1 2.67 65.39
0.25 23.6 0.37* 143.9 4.25 103.0 2.69 67.02
5.0 22.4 0.41 144.2 4.52** 103.0 2.69 66.97
90 days post exposure
0 27.9 0.77 145.5 4.52 103.4 2.75 69.08
0.05 25.5* 0.68 145.7 4.59 103.2 2.77 68.42
0.25 24.4** 0.75 145.9 4.58 104.4 2.71 67.41
5.0 26.3 0.79 145.8** 4.73 104.5 2.74- 68.24
FEMALE
HCDb, c 25.0 - 41.7 0.18 - 0.57 137.8 - 147.8 2.73 - 3.90 100.6 - 110.3 2.53 - 2.99 63.62 - 79.36
24 h post exposure
0 30.4 0.32 143.5 3.43 102.0 2.75 72.27
0.05 27.7 0.31 144.8 3.95** 103.8 2.76 71.50
0.25 28.3 0.35 144.0 4.17** 103.4 2.80 72.87
5.0 27.3* 0.30 145.8 3.81* 105.3** 2.72 69.27*
90 days post exposure
0 28.8 0.72 143.5 3.40 101.7 2.78 77.11
0.05 31.9 0.60 146.4** 3.41 104.1 2.76 74.74
0.25 30.1 0.54* 144.9 3.21 101.9 2.72* 74.78
5.0 30.6 0.47** 145.1 3.54 104.0 2.74 72.29**
  1. * p < 0.05, ** p < 0.01; statistical significant differences to controls
  2. a No statistically significant changes were observed at any concentrations and time-points on glucose, urea, bilirubin, cholesterol, triglycerides, phospholipids, aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), creatine kinase (CK), phosphorus, albumin and globulin
  3. b HCD Historical control data, 95 % tolerance limits
  4. c Changes statistically significant outside the HCD are in italic characters