Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats

Table 4 Cell analysis in the BALF of male and female rats 24 h and 90 days after a 90-day exposure to Graphistrength^© C100

Concentration (mg/m³)	Total cell Count	Viability	Macrophages	Eosinophils	Lymphocytes	Neutrophils	Epithelial cells
	10⁶	%	%	%	%	%
MALE
24 h post exposure
0	1.74	84.40	93.9	0.0	4.4	1.5	0.1
0.05	1.62	84.65	91.8	0.0	5.1	3.1	0.0
0.25	2.24	89.00	64.8**	0.0	9.7*	25.2**	0.3
5.0	2.01	88.00	31.5**	0.0	12.8**	55.6**	0.1
90 days post exposure
0	1.80	90.10	96.5	0.0	2.1	1.2	0.2
0.05	2.21	91.35	96.9	0.0	1.9	0.9	0.3
0.25	2.85*	91.35	91.2	0.1	3.8	4.7	0.3
5.0	6.23**	89.86	44.6**	0.0	20.4**	39.8**	0.3
FEMALE
24 h post exposure
0	1.67	91.80	96.9	0.0	2.5	0.4	0.1
0.05	1.27	92.55	94.5	0.0	4.4	1.0	0.1
0.25	2.16	92.55	80.9**	0.0	4.1	15.0**	0.0
5.0	2.98**	95.50	34.7**	0.0	11.5**	53.8**	0.0
90 days post exposure
0	1.67	86.39	96.1	0.0	3.1	0.5	0.2
0.05	1.66	85.40	95.8	0.0	3.4	0.8	0.0
0.25	1.86	87.55	93.9	0.0	3.3	2.8	0.0
5.0	4.02**	88.80	46.7**	0.0	13.0**	40.1**	0.0

ISSN: 1743-8977