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Table 4 Cell analysis in the BALF of male and female rats 24 h and 90 days after a 90-day exposure to Graphistrength© C100

From: Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats

Concentration (mg/m3) Total cell Count Viability Macrophages Eosinophils Lymphocytes Neutrophils Epithelial cells
  106 % % % % %  
MALE
24 h post exposure
0 1.74 84.40 93.9 0.0 4.4 1.5 0.1
0.05 1.62 84.65 91.8 0.0 5.1 3.1 0.0
0.25 2.24 89.00 64.8** 0.0 9.7* 25.2** 0.3
5.0 2.01 88.00 31.5** 0.0 12.8** 55.6** 0.1
90 days post exposure
0 1.80 90.10 96.5 0.0 2.1 1.2 0.2
0.05 2.21 91.35 96.9 0.0 1.9 0.9 0.3
0.25 2.85* 91.35 91.2 0.1 3.8 4.7 0.3
5.0 6.23** 89.86 44.6** 0.0 20.4** 39.8** 0.3
FEMALE
24 h post exposure
0 1.67 91.80 96.9 0.0 2.5 0.4 0.1
0.05 1.27 92.55 94.5 0.0 4.4 1.0 0.1
0.25 2.16 92.55 80.9** 0.0 4.1 15.0** 0.0
5.0 2.98** 95.50 34.7** 0.0 11.5** 53.8** 0.0
90 days post exposure
0 1.67 86.39 96.1 0.0 3.1 0.5 0.2
0.05 1.66 85.40 95.8 0.0 3.4 0.8 0.0
0.25 1.86 87.55 93.9 0.0 3.3 2.8 0.0
5.0 4.02** 88.80 46.7** 0.0 13.0** 40.1** 0.0
  1. * p < 0.05, ** p < 0.01; statistical significant differences to controls