|
Males
|
Females
|
---|
Target concentration (mg/m3)
|
0
|
0.05
|
0.25
|
5.0
|
0
|
0.05
|
0.25
|
5.0
|
Number examined
|
10/10
|
10/8
|
10/9
|
10/10
|
10/8
|
9/10
|
10/10
|
10/10
|
(24 h/90 days)
|
Black particle deposition
| | | | | | | | |
minimal
|
-
|
-
|
8/5
|
-
|
-
|
-
|
5/3
|
1
|
slight
|
-
|
-
|
-/2
|
6/3
|
-
|
-
|
-
|
7/1
|
moderate
|
-
|
-
|
-
|
4/7
|
-
|
-
|
-
|
1/9
|
Mean severitya
|
-
|
-
|
0.8/0.9
|
2.4/2.7
|
-
|
-
|
0.5/0.3
|
1.8/2.9
|
Increased lymphocytes, cortex/paracortex
| | | | | | | | |
minimal
|
-
|
-
|
3/-
|
4/7
|
-
|
-
|
1/-
|
3/6
|
slight
|
-
|
-
|
-
|
3/2
|
-
|
-
|
-
|
7/-
|
moderate
|
-
|
-
|
-
|
3/-
|
-
|
-
|
-
|
-
|
Mean severitya
|
-
|
-
|
0.3/-
|
1.9/1.1
|
-
|
-
|
0.1/-
|
1.7/0.6
|
Endothelial vacuolation, high endothelial venule
| | | | | | | | |
minimal
|
-
|
-
|
1/-
|
1/2
|
-
|
-
|
-
|
2/5
|
slight
|
-
|
-
|
1/-
|
7/1
|
-
|
-
|
-
|
5/-
|
Mean severitya
|
-
|
-
|
0.3/-
|
1.5/0.4
|
-
|
-
|
-
|
1.2/0.5
|
- Histopathological findings were graded in severity using a five point system of minimal (grade 1), slight (grade 2), moderate (grade 3), marked (grade 4) or severe (grade 5)a: mean severity is ∑ number of animals x severity / number of examined organs in the group
-
a: mean severity is ∑ number of animals x severity / number of examined organs in the group - : no animal affected