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Fig. 10 | Particle and Fibre Toxicology

Fig. 10

From: Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

Fig. 10

Representative images of immunofluorescence expression of IL-1β in the cerebral parenchyma of (a) control rats, or tissues collected from rats treated with 1 mg/kg TiO2 (IV) at (b) 5 min; (c) 6 h; (d) 24 h; or (e) 28 days post-treatment. Arrows indicate sagittal suture (coronal cut, sections cut and analyzed between rostral and caudal diencephalon). Graph in (f) shows analysis of relative fluorescence of overlay images ± SD. *P < 0.050 compared to controls

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