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Fig. 12 | Particle and Fibre Toxicology

Fig. 12

From: Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

Fig. 12

Schematic summary of the events and potential effects on BBB physiology in the case of bioaccumulation of TiO2 NPs in organs. Exposure to circulating mediators that maybe originate from organs bioaccumulating titanium leads to neurovascular inflammation. Overexpression of IL-1β, CXCL1 and IP-10 may contribute to modification of brain endothelial cell physiology in terms of expression of tight junction proteins (occludin and claudin-5) and ABC transporters (P-gp and BCRP). In parallel, key inflammatory markers for glial and endothelial cells interactions were upregulated

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