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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

Fig. 3

Titanium quantification in rat brain (a), isolated brain microvasculature endothelial cells (b) and brain parenchyma (c) of treated (grey) and control (white) animals after IV injection of 1 mg/kg TiO2 NPs and schematic summary of the events and potential effects on the BBB.. Quantification by inductively coupled plasma mass spectrometry (ICP-MS). Each data point represents the mean ± SD of n = 6 animals. Statistical comparison was performed by two-way ANOVA, *P < 0.05; **P < 0.01; ***P < 0.001. Consequences and hypothesis of clearance mechanism of TiO2 NPs at the BBB (d). Transient presence of TiO2 NPs in brain microvasculature endothelial cells leads to overexpression of cytokines and chemokines (IL-1β and IP-10), which could be linked to the modification of activity or expression of P-gp and BCRP. Integrity of the barrier is not compromised

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