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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

Fig. 4

mRNA expression of tight junction proteins occludin (a, b) and claudin 5 (c, d) in isolated brain microvasculature endothelial cells 24 h or 28 days after IV injection of 1 mg/kg TiO2 NPs in rats. RT-qPCR was performed in duplicate for each single brain microvasculature endothelial cells preparation. Each data point represents the mean ± SEM of n = 4 animals. Statistical comparison was performed by two tailed Mann-Whitney test, ** P < 0.01. For occludin mRNA expression P = 0.057

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