Skip to main content
Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat

Fig. 6

2Representative images of immunofluorescence expression of tight junction protein occludin (red) and endothelial cell marker vonWillenbrand factor (vWF, green) in the cerebral microvasculature of (a) control rats, or tissues collected from rats treated with 1 mg/kg TiO2 (IV) at (b) 5 min; (c) 6 h; (d) 24 h; or (e) 28 days post-treatment. Yellow fluorescence indicates overlay (co-localization) of occludin and vWF. Arrows indicate areas of increased yellow fluorescence. Graph in (f) shows analysis of relative fluorescence of overlay images ± SD. * P < 0.050 compared to controls

Back to article page
\