Fig. 7From: Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in ratBBB integrity assessment. The integrity was estimated by the ratio between atenolol concentrations in brain and plasma (partition coefficient or Kp) at 6 h, 24 h, 7 days and 28 days after IV administration. Each data point represents the mean ± SD of n = 4 rats. Statistical comparison was performed by two-way ANOVABack to article page