Fig. 7
Plasma endothelin isoforms. Mean fold-effect ± SEM. a. BET-1. 3-way ANOVA and 2-way ANOVA, Ozone × EHC-93, p < 0.001. Tukey multiple comparisons, lines, p < 0.05. b. ET-1. 3-way ANOVA and 2-way ANOVA, Ozone × EHC-93, p < 0.001. Tukey multiple comparisons, lines, p < 0.05. c. ET-2, not significant. d. ET-3. 3-way ANOVA, Ozone × EHC-93, p = 0.021. Tukey, *0 vs 0.8 ppm O3 within 0 mg/m3 EHC-93. E. Ratio ET-1/BET-1. 3-way ANOVA, Ozone × EHC-93, p < 0.001 and EHC-93 × Recovery, p = 0.041. Tukey, *0 vs 50 mg/m3 EHC-93 within 24 h recovery, #0 h vs 24 h within 50 mg/m3 EHC-93, †0 vs 0.8 ppm O3 within 0 mg/m3 EHC-93, &0 vs 50 mg/m3 EHC-93 within 0 ppm O3, p < 0.05. 2-way ANOVA, Ozone × EHC-93, p = 0.006. Tukey comparisons, lines, p < 0.05. f. Ratio ET-1/ET-3. 3-way ANOVA, Ozone × EHC-93, p < 0.001. Tukey, *0 vs 0.8 ppm O3 within 50 mg/m3 EHC-93, #0 vs 0.8 ppm O3 within 0 mg/m3 EHC-93, †0 vs 50 mg/m3 within 0 and 0.8 ppm O3, p < 0.05. 2-way ANOVA, Ozone × EHC-93, p = 0.001. Tukey, lines, p < 0.05. For detailed statistics, refer to Additional files 5 & 7. (Sample size, n = 7–8/air pollutant exposure group; n = 14/air control group)