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Table 3 Cerium concentration in different tissues at 7 days after gavage administration of uncoated or silica-coated CeO2 NPs

From: Silica coating influences the corona and biokinetics of cerium oxide nanoparticles

 

CeO2

Silica-coated CeO2

 

ng/g ± SE

ng/g ± SE

Lungs

0.27 ± 0.16

0.07 ± 0.03

Liver

0.11 ± 0.04

0.07 ± 0.03

Bone

0.55 ± 0.31

0.06 ± 0.06

Cecum

0.22 ± 0.08

0.18 ± 0.13

Large intestine

0.76 ± 0.72

0.20 ± 0.15

Bone marrow

0.00 ± 0.00

0.25 ± 0.25

Spleen

0.06 ± 0.06

0.15 ± 0.15

Stomach

0.31 ± 0.18

2.64 ± 1.84

Kidneys

0.13 ± 0.13

0.09 ± 0.04

Small intestine

0.12 ± 0.05

0.39 ± 0.27

Heart

0.34 ± 0.21

0.35 ± 0.21

Testes

0.04 ± 0.04

0.09 ± 0.04

Skeletal muscle

0.06 ± 0.05

0.01 ± 0.01

Brain

0.05 ± 0.05

0.00 ± 0.00

Skin

0.04 ± 0.04

0.04 ± 0.02

Plasma

0.04 ± 0.04

0.03 ± 0.03

RBC

0.00 ± 0.00

0.03 ± 0.03

  1. Data are mean ± SE ng/g cerium concentration, n = 5/group
  2. Ce concentration was estimated (ng/μCiNPs x μCi/gtissue)
  3. No significant difference was observed between the two group
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Particle and Fibre Toxicology

ISSN: 1743-8977

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