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Table 4 Cerium concentration in different tissues at 2 hours after intravenous injection of uncoated or silica-coated CeO2 NPs

From: Silica coating influences the corona and biokinetics of cerium oxide nanoparticles

 

CeO2

Silica-coated CeO2

 

ng/g ± SE

ng/g ± SE

Lungs

14.37 ± 1.79

54.62 ± 4.93 *

Liver

1951.79 ± 44.49

1663.68 ± 67.67 *

Bone

3.38 ± 0.44

6.42 ± 1.14 *

Cecum

0.62 ± 0.43

0.21 ± 0.03

Large intestine

0.36 ± 0.09

0.28 ± 0.05

Bone marrow

1.73 ± 0.34

4.67 ± 0.70 *

Spleen

1680.71 ± 357.91

1204.38 ± 171.76

Stomach

3.77 ± 1.67

4.77 ± 2.38

Kidneys

3.09 ± 1.44

5.27 ± 0.29

Small intestine

1.37 ± 0.20

1.12 ± 0.14

Heart

0.77 ± 0.15

1.41 ± 0.26

Testes

0.09 ± 0.02

0.19 ± 0.01 *

Skeletal muscle

0.16 ± 0.05

0.23 ± 0.01

Brain

0.04 ± 0.00

0.11 ± 0.02 *

Skin

0.20 ± 0.03

0.68 ± 0.04 *

Plasma

0.14 ± 0.03

0.14 ± 0.03

RBC

2.66 ± 0.51

2.07 ± 0.23

  1. Data are mean ± SE ng/g cerium concentration, n = 5/group
  2. Ce concentration was estimated (ng/μCiNPs x μCi/gtissue)
  3. *P < 0.05, CeO2 vs. silica-coated CeO2