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Table 4 Cerium concentration in different tissues at 2 hours after intravenous injection of uncoated or silica-coated CeO2 NPs

From: Silica coating influences the corona and biokinetics of cerium oxide nanoparticles

  CeO2 Silica-coated CeO2
  ng/g ± SE ng/g ± SE
Lungs 14.37 ± 1.79 54.62 ± 4.93 *
Liver 1951.79 ± 44.49 1663.68 ± 67.67 *
Bone 3.38 ± 0.44 6.42 ± 1.14 *
Cecum 0.62 ± 0.43 0.21 ± 0.03
Large intestine 0.36 ± 0.09 0.28 ± 0.05
Bone marrow 1.73 ± 0.34 4.67 ± 0.70 *
Spleen 1680.71 ± 357.91 1204.38 ± 171.76
Stomach 3.77 ± 1.67 4.77 ± 2.38
Kidneys 3.09 ± 1.44 5.27 ± 0.29
Small intestine 1.37 ± 0.20 1.12 ± 0.14
Heart 0.77 ± 0.15 1.41 ± 0.26
Testes 0.09 ± 0.02 0.19 ± 0.01 *
Skeletal muscle 0.16 ± 0.05 0.23 ± 0.01
Brain 0.04 ± 0.00 0.11 ± 0.02 *
Skin 0.20 ± 0.03 0.68 ± 0.04 *
Plasma 0.14 ± 0.03 0.14 ± 0.03
RBC 2.66 ± 0.51 2.07 ± 0.23
  1. Data are mean ± SE ng/g cerium concentration, n = 5/group
  2. Ce concentration was estimated (ng/μCiNPs x μCi/gtissue)
  3. *P < 0.05, CeO2 vs. silica-coated CeO2