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Table 5 Cerium concentration in different tissues at 2 days after intravenous injection of uncoated or silica-coated CeO2 NPs

From: Silica coating influences the corona and biokinetics of cerium oxide nanoparticles

 

CeO2

Silica-coated CeO2

 

ng/g ± SE

ng/g ± SE

Lungs

5.65 ±1.53

23.15 ± 2.83 *

Liver

1904.43 ± 93.22

1652.57 ± 38.07 *

Bone

2.72 ± 0.64

10.95 ± 1.61 *

Cecum

0.15 ± 0.02

0.95 ± 0.26 *

Large intestine

0.21 ± 0.03

1.07 ± 0.29 *

Bone marrow

1.42 ± 0.28

6.64 ± 1.23 *

Spleen

1096.02 ± 333.49

1822.33 ± 181.83

Stomach

2.01 ± 0.89

3.29 ± 1.25

Kidneys

1.32 ± 0.18

6.32 ± 0.58 *

Small intestine

1.47 ± 0.14

0.63 ± 0.12 *

Heart

0.75 ± 0.26

1.05 ± 0.12

Testes

0.02 ± 0.01

0.20 ± 0.02 *

Skeletal muscle

0.05 ± 0.01

0.18 ± 0.02 *

Brain

0.02 ± 0.01

0.08 ± 0.02 *

Skin

0.19 ± 0.03

0.52 ± 0.08 *

Plasma

0.02 ± 0.01

0.09 ± 0.02 *

RBC

0.30 ± 0.69

0.69 ± 0.03 *

  1. Data are mean ± SE ng/g cerium concentration, n = 5/group
  2. Ce concentration was estimated (ng/μCiNPs x μCi/gtissue)
  3. *P < 0.05, CeO2 vs. silica-coated CeO2