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Table 1 Modulated genes involved in mitochondrial functions

From: An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles

Gene symbol

Main functions

Adjusted P value

Fold change

NDUFA4

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4

6.73E-06

2.365756

NDUFA2

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform 1

3.02E-06

0.374527

NDUFS4

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor

4.13E-06

0.396259

UQCR11

ubiquinol-cytochrome c reductase, complex III subunit XI [Source:HGNC Symbol;Acc:30862]

4.01E-06

2.23789

COX7B

cytochrome c oxidase subunit 7B, mitochondrial precursor

2.16E-07

0.284784

NDUFC2

NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform 1

4.23E-07

0.262135

NDUFA1

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

3.91E-08

0.217706

ATP5H

ATP synthase subunit d, mitochondrial isoform b

3.12E-06

0.400955

TXNDC17

thioredoxin domain-containing protein 17

9.85E-03

2.426058

ATP5S

ATP synthase subunit s, mitochondrial isoform b precursor

6.20E-03

0.273283

ATP6V0B

V-type proton ATPase 21 kDa proteolipid subunit isoform 2

1.34E-03

0.450262

CS

citrate synthase, mitochondrial precursor

7.27E-05

0.464647

DLST

dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 precursor

4.25E-04

0.486408

JUN

transcription factor AP-1

8.43E-04

0.447503

NDUFB11

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform 1

2.57E-02

2.051124

SOD2

superoxide dismutase [Mn], mitochondrial isoform A precursor

6.44E-06

0.476653

TP73

tumor protein p73 isoform d

2.15E-02

0.403954

ATPIF1

ATPase inhibitor, mitochondrial isoform 1 precursor

8.80E-04

2.074952

COX17

cytochrome c oxidase copper chaperone

6.79E-08

0.255958

MRPL11

39S ribosomal protein L11, mitochondrial isoform a

4.50E-06

0.159154

PMPCB

mitochondrial-processing peptidase subunit beta precursor

4.50E-06

0.352621

CYP11A1

cholesterol side-chain cleavage enzyme, mitochondrial isoform a precursor

4.45E-05

2.955856

MRPL52

mitochondrial ribosomal protein L52

2.41E-05

0.452092

HAAO

3-hydroxyanthranilate 3,4-dioxygenase

1.34E-03

0.376486

TOMM20

mitochondrial import receptor subunit TOM20 homolog

6.86E-07

0.321764

MRPL39

39S ribosomal protein L39, mitochondrial isoform b

1.16E-06

0.38445

HSPE1

10 kDa heat shock protein, mitochondrial

2.73E-08

0.239258