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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Platelet activation independent of pulmonary inflammation contributes to diesel exhaust particulate-induced promotion of arterial thrombosis

Fig. 5

Influence of particle injection on thrombogenesis. Diesel exhaust (DEP; black columns) or control particles (carbon black (CB, grey columns)) were administered by intravenous injection 2, 6 or 24 h before induction of arterial thrombosis. (i) Injection of DEP (0.5 mg/rat) reduced time to occlusion (P < 0.05), compared with saline-treated controls (open columns) 2 h (but not 6 or 24 h) after administration. (ii) Injection of carbon black (CB (0.5 mg/rat)) produced a similar reduction in time to occlusion (P < 0.05). (iii) The ratio of tissue plasminogen activator (t-PA) to plasminogen activator inhibitor (PAI)-1 was reduced in the plasma of rats after intravenous injection (IV; 2 h post exposure) of DEP or CB. (iv) Platelet-monocyte interaction was increased following IV administration of DEP but not CB. Data are mean ± s.e.mean (n = 6) and were compared with relevant controls using two way ANOVA (DEP vs Saline) or Student’s unpaired t-test (CB vs Saline). *P < 0.05, **P < 0.01, ***P < 0.001

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