Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals

Table 2 Associations between ambient PM_2.5 moving average time windows and levels of miRNAs in extracellular vesicles (evmiRNAs)

Exposure window	miRNA	Fold change^a	SE	FDR adjusted
Exposure window	miRNA	Fold change^a	SE	P value
1-day
	miR-30d-5p	−0.56	0.17	0.03
	miR-25-3p	−0.30	0.14	0.16
	miR-342-3p	−0.44	0.22	0.20
	miR-106b-5p	−0.56	0.29	0.23
	miR-451a	−0.27	0.16	0.30
1-week
	miR-451a	−0.33	0.15	0.16
	miR-25-3p	−0.21	0.14	0.37
	miR-720	−0.33	0.25	0.44
	miR-4454	−0.29	0.22	0.44
	miR-30d-5p	−0.23	0.20	0.53
1-month
	miR-451a	−0.24	0.15	0.30
	miR-19b-3p	0.17	0.18	0.65
	miR-146a-5p	0.27	0.40	0.78
	miR-150-5p	0.23	0.32	0.78
	miR-1246	−0.43	0.70	0.80
3-month
	miR-19b-3p	0.47	0.17	0.05
	miR-93-5p	0.57	0.25	0.12
	miR-150-5p	0.64	0.28	0.13
	miR-1246	−1.56	0.73	0.17
	miR-142-3p	0.50	0.26	0.22
6-month
	miR-126-3p	0.74	0.21	0.02
	miR-19b-3p	0.52	0.15	0.02
	miR-93-5p	0.78	0.22	0.02
	miR-223-3p	0.74	0.22	0.02
	miR-142-3p	0.81	0.21	0.03
1-year
	miR-23a-3p	0.83	0.23	0.02
	miR-150-5p	0.90	0.24	0.02
	miR-15a-5p	0.70	0.21	0.02
	miR-191-5p	1.20	0.35	0.02
	let-7a-5p	1.42	0.39	0.02

^aEstimated fold change (log₂) of the levels of evmiRNAs per standard deviation (SD) increase in ambient PM_2.5 levels for every time window; all models were adjusted for age, body mass index (BMI), pack-years of smoking, total miRNA counts, and the number of red blood cells (RBCs), white blood cells (WBCs), and platelets; SE indicates standard error

ISSN: 1743-8977