Table 1 Function-related clusters of differentially expressed genes for 21d BDS mice sacrificed immediately after the last exposure ended vs. air controls (fold change > 2 and FDR p-value < 0.05)

Inflammation cluster

Saa3

serum amyloid A 3

7.86

Cxcl1

chemokine (C-X-C motif) ligand 1

5.42

Reg3g

regenerating islet-derived 3 gamma

4.75

Orm1

orosomucoid 1

4.73

Cxcl5

chemokine (C-X-C motif) ligand 5

4.43

Ccl20

chemokine (C-C motif) ligand 20

3.60

Vnn1

vanin 1

3.30

Adam8

a disintegrin and metallopeptidase domain 8

3.13

Cfb

complement factor B

2.61

Cxcl2

chemokine (C-X-C motif) ligand 2

2.33

Cd14

CD14 antigen

2.07

Ptgs2

prostaglandin-endoperoxide synthase 2

2.06

Ccl28

chemokine (C-C motif) ligand 28

1.96

Biotransformation cluster

Cyp1b1

cytochrome P450, family 1, subfamily b, polypeptide 1

25.83

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

18.32

Aldh3a1

aldehyde dehydrogenase family 3, subfamily A1

7.97

Ahrr

aryl-hydrocarbon receptor repressor

3.56

Adh7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

3.35

Scgb3a1

secretoglobin, family 3A, member 1

3.21

Ltf

lactotransferrin

2.50

Afp

alpha fetoprotein

2.31

Steap4

STEAP family member 4

2.07

Itih4

inter alpha-trypsin inhibitor, heavy chain 4

2.02

Oxidative stress cluster

Nqo1

NAD(P)H dehydrogenase, quinone 1

4.16

Ces1

carboxylesterase 1

3.88

Akr1b8

aldo-keto reductase family 1, member B8

2.02

Acox2

acyl-Coenzyme A oxidase 2, branched chain

2.01

Gpx2

Glutathione peroxidase 2

1.97