Fig. 2

Histological and pathological observations for mice received multi-dose administration of AgNPs or AgNO₃. Mice were injected with 25 μg AgNPs or AgNO₃ solution containing 2.5 μg Ag on Day 1, 4 and 10. Tissue samples of liver, kidney, and lung were collected on the day 7 after the last injection. a The representative image of liver. The scale bar in the image represents 100 μm. b Magnification of a. The scale bar represents 20 μm. c-d Morphological observation of kidney. e H&E staining of lung. The inserted image in each image is the magnified area of the blue boxes in the rectangle; the short scale bar is 20 μm. The long scale bar represents 100 μm. Yellow arrow heads point to inflammatory cells around the vessels