The MWCNT sub-clusters include pro-fibrotic genes that can differentiate MWCNT from less fibrotic nanomaterials.
a A list of fibrosis genes was obtained from the IPA database and the overlapping genes shortlisted in the pink and blue clusters, as well as the genes identified as upstream regulators of the pink and blue cluster shortlists, are indicated. b The fibrosis gene list from IPA was also applied to gene shortlists from CNT, TiO2, and CB datasets that were included in this meta-analysis with the same dose and time points to show the differences in gene expression between MWCNTs and other less fibrotic nanomaterials. Genes from Fig. 5a are highlighted in yellow