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Table 1 A list of the studies that were included in the meta-analysis and the experimental details

From: Meta-analysis of transcriptomic responses as a means to identify pulmonary disease outcomes for engineered nanomaterials

Reference Nanomaterial/Chemical Route of exposure Mouse strain Dose Post-exposure time point Array platform GSE
Poulsen et al. (2015) [8] Carbon nanotubes Intratracheal Adult C57BL/6 Single dose of 18, 54, 162 μg/mouse 1, 3, and 28 days Agilent whole genome GSE35284
Bourdon et al. (2012) [10] Carbon black Intratracheal Adult C57BL/6 Single dose of 18, 54, 162 μg/mouse 1, 3, and 28 days Agilent whole genome GSE35193
Halappanavar et al. (2011) [13] Nano titanium dioxide Inhalation Adult C57BL/6 1 h daily for 11 consecutive days to 42.4 mg 5 days Agilent whole genome GSE19487
Guo et al. (2012) [14] Carbon nanotubes Pharyngeal aspirations Adult C57BL/6 Single dose of 0, 10, 20, 40, or 80 μg of CNT/mouse 1, 7, 28, and 56 days Agilent whole genome GSE29042
Reference not available Bleomycin Intratracheal Adult Balb-c and C57BL6 Single dose of 0 and 1.5 U/kg body weight 24 h, 72 h, 10 day and 14 days Affymetrix murine genome GSE485
Erdely et al. (2012) [15] Gas metal arc - stainless steel welding fume Inhalation Adult C57BL6 0 or 40 mg/m3, 3 h daily for 10 consecutive days 4 h, 14 days, 28 days Illumina mouse bead array GSE34056
Zeidler-Erderly et al. (2010) [16] Gas metal arc—stainless steel welding fume Pharyngeal aspiration Adult A/J or C57BL/6 J Four doses of 85 mg/kg 4 and 16 weeks Illumina mouse bead array GSE20174
Lewis et al. (2008) [17] 12 different lung disease model datasets including bleomycin, Th2 responses, and infection models Differs with the model of lung disease Differs with the model of lung disease Differs with the model of lung disease Differs with the model of lung disease UCSF &Mm mouse oligo array GSE4231
Halappanavar et al. (2015) [7] Nano titanium dioxide Intratracheal Adult C57BL/6 Single dose of 18, 54, 162, or 486 μg/mouse 1 and 28 days Agilent whole genome GSE60801
Husain et al. (2015) [19] Carbon Black Intratracheal Adult C57BL/6 Single dose of 162 μg/mouse 3 h, and 2, 3, 4, 5, 14, and 42 days Agilent whole genome GSE68036
Rahman et al. (manuscript in preparation) Carbon nanotubes Intratracheal Adult C57BL/6 4 doses of 128 or 47.5 μg/mouse per week 60 days Agilent whole genome GSE65623
Thomson et al. (2012) [18] Lung-specific TNFα over-expression N/A Adult C57BL/6 and transgenic mice N/A N/A Agilent whole genome GSE11037