Table 1 A list of the studies that were included in the meta-analysis and the experimental details
Reference | Nanomaterial/Chemical | Route of exposure | Mouse strain | Dose | Post-exposure time point | Array platform | GSE |
|---|---|---|---|---|---|---|---|
Poulsen et al. (2015) [8] | Carbon nanotubes | Intratracheal | Adult C57BL/6 | Single dose of 18, 54, 162 μg/mouse | 1, 3, and 28 days | Agilent whole genome | GSE35284 |
Bourdon et al. (2012) [10] | Carbon black | Intratracheal | Adult C57BL/6 | Single dose of 18, 54, 162 μg/mouse | 1, 3, and 28 days | Agilent whole genome | GSE35193 |
Halappanavar et al. (2011) [13] | Nano titanium dioxide | Inhalation | Adult C57BL/6 | 1Â h daily for 11 consecutive days to 42.4Â mg | 5Â days | Agilent whole genome | GSE19487 |
Guo et al. (2012) [14] | Carbon nanotubes | Pharyngeal aspirations | Adult C57BL/6 | Single dose of 0, 10, 20, 40, or 80 μg of CNT/mouse | 1, 7, 28, and 56 days | Agilent whole genome | GSE29042 |
Reference not available | Bleomycin | Intratracheal | Adult Balb-c and C57BL6 | Single dose of 0 and 1.5 U/kg body weight | 24Â h, 72Â h, 10 day and 14 days | Affymetrix murine genome | GSE485 |
Erdely et al. (2012) [15] | Gas metal arc - stainless steel welding fume | Inhalation | Adult C57BL6 | 0 or 40Â mg/m3, 3Â h daily for 10 consecutive days | 4Â h, 14Â days, 28Â days | Illumina mouse bead array | GSE34056 |
Zeidler-Erderly et al. (2010) [16] | Gas metal arc—stainless steel welding fume | Pharyngeal aspiration | Adult A/J or C57BL/6 J | Four doses of 85 mg/kg | 4 and 16 weeks | Illumina mouse bead array | GSE20174 |
Lewis et al. (2008) [17] | 12 different lung disease model datasets including bleomycin, Th2 responses, and infection models | Differs with the model of lung disease | Differs with the model of lung disease | Differs with the model of lung disease | Differs with the model of lung disease | UCSF &Mm mouse oligo array | GSE4231 |
Halappanavar et al. (2015) [7] | Nano titanium dioxide | Intratracheal | Adult C57BL/6 | Single dose of 18, 54, 162, or 486 μg/mouse | 1 and 28 days | Agilent whole genome | GSE60801 |
Husain et al. (2015) [19] | Carbon Black | Intratracheal | Adult C57BL/6 | Single dose of 162 μg/mouse | 3 h, and 2, 3, 4, 5, 14, and 42 days | Agilent whole genome | GSE68036 |
Rahman et al. (manuscript in preparation) | Carbon nanotubes | Intratracheal | Adult C57BL/6 | 4 doses of 128 or 47.5 μg/mouse per week | 60 days | Agilent whole genome | GSE65623 |
Thomson et al. (2012) [18] | Lung-specific TNFα over-expression | N/A | Adult C57BL/6 and transgenic mice | N/A | N/A | Agilent whole genome | GSE11037 |