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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Atomic layer deposition coating of carbon nanotubes with zinc oxide causes acute phase immune responses in human monocytes in vitro and in mice after pulmonary exposure

Fig. 5

a Micrographs of cell populations from BAL fluid showing U-MWCNTs, but not Z-MWCNTs, taken up by macrophages at one day post-exposure. Arrows represent neutrophils. b Quantification of U-MWCNTs or Z-MWCNTs within macrophages at one and 28 days. One day after nanotube exposure more than 50 % of the macrophage population of U-MWCNT-treated mice have visibly engulfed MWCNTs while only about 10 % of the macrophages present in the Z-MWCNT treated mice have visibly engulfed MWCNTs. This difference evens out by day 28. The number of animals per group at one day was: Control (3), U-MWCNT (4), Z-MWCNT (4) and at 28 days was: Control (4), U-MWCNT (5), Z-MWCNT (3). Significance is represented as ### (P < 0.001) between U-MWCNT and Z-MWCNT at one day post-exposure

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