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Fig. 10 | Particle and Fibre Toxicology

Fig. 10

From: Evaluation of pulmonary and systemic toxicity following lung exposure to graphite nanoplates: a member of the graphene-based nanomaterial family

Fig. 10

Serum Proteins and Systemic Gene Expression. Data in the table (a) represents fold-increase for serum proteins that were significantly different for one or more groups at 4 h and 1 day post-exposure based on RodentMap® v2.0; only high dose groups were analyzed. BLD – below the limit of detection; astatistically different from DM only; bstatistically different DM, Gr1 - High and CB - High groups; cstatistically different from all groups; p < 0.05. b Relative mRNA expression by qPCR of select genes in liver at 1 day post-exposures. Low dose exposures were not evaluated in liver as pilot experiments showed no response. c Relative mRNA expression of select genes by qPCR in whole blood cells at 4 h post-exposure (d) Relative mRNA expression of select genes by qPCR in aorta at 4 h post-exposure. *significantly different from all groups; #significantly different from DM only; ^significantly different from DM, Gr20-Low, Gr5-Low, and Gr1-Low; p < 0.05

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