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Table 1 Histopathology analysis of lung tissue following exposure to 40 μg of particles

From: Evaluation of pulmonary and systemic toxicity following lung exposure to graphite nanoplates: a member of the graphene-based nanomaterial family

Treatment Group Time Post-Exposure AII BI TBI BHH
Gr20 7 day - 0.17 (1/6) 1.7 (6/6) 1.0 (5/6)
Gr5 7 day - - 1.0 (5/6) -
Gr1 7 day - - - -
CB 7 day - - 0.5 (3/6) 0.17 (1/6)
Gr20 1 month 0.17 (1/6) - 0.7 (4/6) 0.7 (4/6)
Gr5 1 month - - 0.7 (2/6) 0.5 (3/6)
Gr1 1 month - - - -
CB 1 month - - - -
Gr20 2 months - - 0.7 (4/6) 0.83 (5/6)
Gr5 2 months 0.3 (2/6) - - 0.5 (3/6)
Gr1 2 months - - - -
CB 2 months - - - -
  1. Lung tissue was analyzed for alveolar interstitial inflammation (AII), bronchiolar inflammation (BI), terminal bronchiolar inflammation (TBI), and bronchiolar hypertrophy or hyperplasia (BHH), type II cell hypertrophy, BALT, lipidosis, fibrosis (n = 6 per group per time point). Severity was scored as 0-5: 0 = normal, 1 = minimal/slight, 2 = mild, 3 = moderate, 4 = marked, and 5 = severe. Data are presented as means in bold with incidence (number of animals with a positive score per total animals) in parentheses. No changes in type II cell hypertrophy, BALT, lipidosis, or fibrosis were noted with the exception of one 1 animal from the Gr20 group at 2 months that had one fibrotic focal area scored as 1