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Table 3 BALF protein analysis at 2 months post-exposure

From: Evaluation of pulmonary and systemic toxicity following lung exposure to graphite nanoplates: a member of the graphene-based nanomaterial family

Protein Gr20 - High Gr5 - High Protein Gr20 - High Gr5 - High
Apo A-1 1.53 0.99 MIP - 1α 1.33 1.44
Crp Mouse 1.00 1.19** MIP - 1β 1.13 1.61**
Eotaxin 1.37* 1.52* MIP - 1γ 2.54* 4.08*
EGF Mouse 3.93 1.52 MIP - 2 1.65 2.26**
Fibrinogen 1.07 1.32 MIP - 3 1.36 1.57
GCP-2 Mouse 1.37 1.37 MMP-9 2.28 3.47
GM-CSF BLD BLD MCP-1 BLD 2.47
KC/GRO BLD BLD MCP-3 0.58 5.64**
IgA 1.05 2.01** MCP-5 BLD BLD
IP-10 1.42 2.11 PAI-1 1.02 1.36**
IL-1α 0.79 3.16 SAP BLD BLD
IL-1 \( \boldsymbol{\upbeta} \) BLD BLD SCF 0.78 0.94
IL-5 BLD BLD Thrombopoetin 1.90 2.52
IL-6 1.12 2.48** TIMP-1 1.20* 1.37**
IL-18 2.31 3.50* TNF-α BLD BLD
LIF 1.48 1.73* VCAM-1 1.40* 1.46*
M-CSF-1 1.13 1.48** VEGF-A 0.74 0.79
MDC 2.01* 2.38* vWF 1.41 1.46
  1. Data in the table represent fold-increase for proteins that were significantly different for one or more groups at one or more time points post-exposure based on RodentMap® v3.0 (Does not include CD40, CD40L, Lymphotactin, MPO, and osteopontin). BLD – below the limit of detection; ** -statistically different from Gr20 and DM; *- statistically different from DM; p < 0.05. Bold text without symbols denotes significance at p < 0.07