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Table 3 BALF protein analysis at 2 months post-exposure

From: Evaluation of pulmonary and systemic toxicity following lung exposure to graphite nanoplates: a member of the graphene-based nanomaterial family

Protein

Gr20 - High

Gr5 - High

Protein

Gr20 - High

Gr5 - High

Apo A-1

1.53

0.99

MIP - 1α

1.33

1.44

Crp Mouse

1.00

1.19**

MIP - 1β

1.13

1.61**

Eotaxin

1.37*

1.52*

MIP - 1γ

2.54*

4.08*

EGF Mouse

3.93

1.52

MIP - 2

1.65

2.26**

Fibrinogen

1.07

1.32

MIP - 3

1.36

1.57

GCP-2 Mouse

1.37

1.37

MMP-9

2.28

3.47

GM-CSF

BLD

BLD

MCP-1

BLD

2.47

KC/GRO

BLD

BLD

MCP-3

0.58

5.64**

IgA

1.05

2.01**

MCP-5

BLD

BLD

IP-10

1.42

2.11

PAI-1

1.02

1.36**

IL-1α

0.79

3.16

SAP

BLD

BLD

IL-1 \( \boldsymbol{\upbeta} \)

BLD

BLD

SCF

0.78

0.94

IL-5

BLD

BLD

Thrombopoetin

1.90

2.52

IL-6

1.12

2.48**

TIMP-1

1.20*

1.37**

IL-18

2.31

3.50*

TNF-α

BLD

BLD

LIF

1.48

1.73*

VCAM-1

1.40*

1.46*

M-CSF-1

1.13

1.48**

VEGF-A

0.74

0.79

MDC

2.01*

2.38*

vWF

1.41

1.46

  1. Data in the table represent fold-increase for proteins that were significantly different for one or more groups at one or more time points post-exposure based on RodentMap® v3.0 (Does not include CD40, CD40L, Lymphotactin, MPO, and osteopontin). BLD – below the limit of detection; ** -statistically different from Gr20 and DM; *- statistically different from DM; p < 0.05. Bold text without symbols denotes significance at p < 0.07