Control | EPOXY-REF | EPOXY-CNT | EPOCYL | CBa | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 day | 0 μg | 54 μg | 162 μg | 486 μg | 54 μg | 162 μg | 486 μg | 54 μg | 162 μg | 486 μg | 162 μg | |
Neutrophils (x103) | 9.4 ± 2.5 | 37.8 ± 5.0** | 110.1 ± 20.8*** | 189.3 ± 16.2*** | 72.7 ± 8.8*** | 154.4 ± 20.1*** | 182.3 ± 22.2*** | 42.0 ± 7.8** | 149.7 ± 12.1*** | 188.3 ± 15.2*** | 143.7 ± 26.1*** | |
Macrophages (x103) | 62.8 ± 5.9 | 93.5 ± 14.7 | 72.3 ± 16.7 | 49.3 ± 6.8 | 62.5 ± 5.1 | 70.6 ± 13.1 | 53.4 ± 2.9 | 85.8 ± 9.5 | 65.3 ± 11.6 | 41.4 ± 7.0 | 18.4 ± 4.5** | |
Eosinophils (x103) | 1.0 ± 0.5 | 19.4 ± 3.7*** | 51.3 ± 8.7*** | 28.1 ± 5.0*** | 48.4 ± 9.4*** | 91.5 ± 13.7*** | 17.4 ± 8.5* | 17.6 ± 5.3** | 58.8 ± 7.9*** | 16.0 ± 7.0** | 20.2 ± 5.7** | |
Lymphocytes (x103) | 0.8 ± 0.2 | 2.8 ± 1.0 | 3.6 ± 1.0 | 4.6 ± 1.2* | 5.2 ± 1.9 | 6.6 ± 2.7 | 6.8 ± 1.3* | 2.1 ± 0.6 | 3.7 ± 1.3 | 3.5 ± 1.2 | 0.9 ± 0.5 | |
Epithelial (x103) | 8.8 ± 1.6 | 9.0 ± 1.7 | 10.7 ± 3.5 | 13.7 ± 4.2 | 9.7 ± 2.5 | 10.8 ± 3.1 | 13.1 ± 2.8 | 9.7 ± 2.2 | 10.6 ± 2.7 | 13.4 ± 1.7 | 9.8 ± 2.1 | |
Total BAL cells (x103) | 82.8 ± 8.3 | 162.4 ± 21.0** | 248.0 ± 38.2*** | 285.0 ± 28.4*** | 198.5 ± 11.1*** | 334.0 ± 29.1*** | 273.0 ± 32.7*** | 157.2 ± 15.4** | 288.0 ± 22.2*** | 262.5 ± 19.9*** | 193 ± 26.4** | |
3 days | ||||||||||||
Neutrophils (x103) | 2.6 ± 1.2 | 5.0 ± 1.3 | 40.9 ± 7.3*** | 94.5 ± 19.7*** | 28.0 ± 8.4*** | 26.2 ± 4.8*** | 113.5 ± 27.3*** | 10.5 ± 1.3** | 50.6 ± 8.6*** | 151.5 ± 17.6*** | 120.2 ± 24.4*** | |
Macrophages (x103) | 57.8 ± 5.8 | 81.0 ± 12.5 | 96.9 ± 10.6 | 111.2 ± 22.2 | 78.0 ± 13.2 | 95.9 ± 16.4 | 125.1 ± 23.5* | 84.8 ± 8.6 | 146.9 ± 11.8*** | 98.6 ± 32.4 | 65.5 ± 16.3 | |
Eosinophils (x103) | 5.3 ± 4.4 | 36.8 ± 5.8*** | 99.6 ± 22.8*** | 30.3 ± 12.9* | 95.4 ± 14.0*** | 139.5 ± 36.1*** | 32.8 ± 9.0* | 56.5 ± 22.1*** | 173.0 ± 47.7*** | 41.8 ± 9.5*** | 43.8 ± 16.3 | |
Lymphocytes (x103) | 1.7 ± 0.6 | 2.8 ± 0.6 | 29.6 ± 7.1*** | 53.7 ± 24.2*** | 10.6 ± 2.9* | 34.2 ± 5.7*** | 35.5 ± 21.9 | 9.3 ± 3.5** | 25.5 ± 5.4*** | 14.0 ± 3.5*** | 3.1 ± 1.4 | |
Epithelial (x103) | 7.1 ± 1.5 | 7.0 ± 0.7 | 9.5 ± 1.7 | 21.9 ± 2.4** | 8.5 ± 2.6 | 10.3 ± 3.0 | 14.1 ± 3.4 | 11.9 ± 2.5 | 14.4 ± 2.6 | 24.6 ± 2.8** | 12.8 ± 4.5 | |
Total BAL cells (x103) | 74.5 ± 8.8 | 132.5 ± 17.2 | 276.5 ± 34.3*** | 311.5 ± 64.4*** | 220.5 ± 33.4*** | 306.0 ± 46.1*** | 321.0 ± 67.9*** | 173.0 ± 30.8*** | 410.5 ± 52.0*** | 330.5 ± 31.6*** | 254.4 ± 28.3*** | |
28 days | ||||||||||||
Neutrophils (x103) | 6.8 ± 4.2 | 3.4 ± 1.4 | 8.8 ± 3.2 | 29.6 ± 5.4** | 6.9 ± 1.7 | 18.2 ± 4.1* | 30.2 ± 5.0*** | 5.3 ± 2.1 | 12.0 ± 2.4 | 53.8 ± 9.8*** | 59.3 ± 8.6*** | |
Macrophages (x103) | 60.3 ± 5.7 | 53.1 ± 11.1 | 74.6 ± 8.4 | 100.2 ± 18.3 | 67.9 ± 12.7 | 93.1 ± 11.2 | 99.3 ± 11.9 | 50.9 ± 5.5 | 75.0 ± 5.9 | 84.2 ± 10.1 | 118.2 ± 29.5 | |
Eosinophils (x103) | 20.4 ± 10.1 | 18.5 ± 8.1 | 3.2 ± 0.7 | 3.2 ± 0.8 | 8.8 ± 2.7 | 6.3 ± 3.4 | 2.2 ± 1.0 | 10.0 ± 3.6 | 2.2 ± 0.9 | 2.5 ± 0.7 | 1.7 ± 1.0 | |
Lymphocytes (x103) | 4.9 ± 1.6 | 6.2 ± 2.1 | 5.7 ± 1.3 | 7.9 ± 1.6 | 4.7 ± 1.4 | 6.3 ± 0.8 | 10.1 ± 3.1 | 10.7 ± 4.0 | 6.4 ± 1.1 | 8.6 ± 1.3 | 36.4 ± 12.6 | |
Epithelial (x103) | 9.8 ± 1.9 | 11.8 ± 3.5 | 7.2 ± 2.6 | 13.5 ± 2.2 | 7.8 ± 2.6 | 7.6 ± 1.8 | 14.6 ± 2.7 | 10.1 ± 3.9 | 11.0 ± 2.1 | 12.9 ± 2.8 | 18.0 ± 3.0 | |
Total BAL cells (x103) | 102.3 ± 16.3 | 93.0 ± 19.2 | 99.5 ± 11.8 | 154.5 ± 18.1** | 96.0 ± 17.0 | 131.5 ± 15.5 | 156.5 ± 12.8 | 87.0 ± 10.4 | 106.5 ± 7.5 | 162.0 ± 16.5* | 233.5 ± 23.7** |